The Active Site: Which Substrate Should Bind there?

by | October 25, 2016


Psalm 37:4 – “Delight thyself also in the Lord: and He shall give thee the desires of thine heart.” (KJV)


Enzymes are proteins or biological catalysts whose primary function is to increase the rate of cellular reactions. A cluster of amino acids combine to form the active site on a single enzyme. This active site has a specific conformation that only allows certain substrates to bind to it so that catalytic activity can progress.

In the cell, other foreign substances compete with the substrate for the active site which are known as inhibitors. During competitive inhibition, these inhibitors bind temporarily to the active site preventing the ‘true’ substrate from binding.

The wonderful thing about this type of inhibition is that it’s reversible and the inhibitors will eventually leave the active site.

Just as the substrate rivals other inhibitors for the active site; our lives face a similar fate. The competition is from Jesus (the substrate) and Satan (the inhibitor) who disguises himself within certain activities.

For we wrestle not against flesh and blood, but against principalities, against powers, against the rulers of the darkness of this world, against spiritual wickedness in high places.” (Ephesians 6:12)

Many speculate as to what may be preventing the true substrate (Jesus) from binding to our hearts. Sometimes it may be education, a favourite TV show, the internet, your job, a boyfriend or girlfriend. What is blocking your active site?

However, it is known that by increasing substrate concentration in a reaction, the possibility of an inhibitor binding to the active site is lowered.

Likewise, in our lives if we increase our communication with Jesus by reading the bible, engaging in constant prayer and helping others, we can prevent idols from taking God’s time and stunting our spiritual growth and development.

Once we make time for God, He has promised us that when we, “Delight ourselves in Him: He shall give us the desires of our heart.” (Psalm 37:4)


THE PRAYER: Lord, I know that I have ill-treated you in the past, but I invite you now to occupy the rightful position in my life. Let nothing prevent you from doing such. Thank you for always loving me. Amen